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What Drugs Cause Elevated Levels of Creatinine?

Mark Halsey
Chief Editor of - Cleanbreak Recovery

Mark Halsey is a licensed therapist, founder, and chief editor of Clean Break Recovery. With over a decade of addiction treatment experience, Mark deeply understands...Read more

If you’re dealing with high levels of creatinine, then you may be wondering what drugs are the cause. High creatinine is often the result of kidney issues, but certain medications may also elevate creatinine levels in the blood. In this article, we’ll discuss what drugs cause elevated levels of creatinine and what you can do to avoid them. Read on to learn more about this important topic.

What Drugs Cause Elevated Levels of Creatinine?

What Medications can Cause High Creatinine Levels?

Creatinine is a waste product produced by the body, which is normally removed from the body through the kidneys. High creatinine levels can be a sign of kidney damage or other health problems, and can be caused by certain medications. It is important to understand which medications can lead to elevated creatinine levels, in order to reduce the risk of kidney damage.

Non-Steroidal Anti-inflammatory Drugs (NSAIDs)

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat pain and inflammation. These drugs work by blocking the action of certain enzymes in the body that cause pain and inflammation. Unfortunately, NSAIDs can also interfere with the kidneys’ ability to filter out creatinine, leading to elevated levels. Common NSAIDs that can cause elevated creatinine levels include ibuprofen, naproxen, celecoxib, and meloxicam.

Diuretics

Diuretics are medications that are used to remove excess fluid from the body, and are commonly prescribed to treat high blood pressure and heart disease. These drugs cause the body to excrete more water and electrolytes, including creatinine, which can lead to elevated creatinine levels. Common diuretics that can cause elevated creatinine levels include furosemide, hydrochlorothiazide, and spironolactone.

What Over-the-Counter Drugs can Cause High Creatinine Levels?

Over-the-counter (OTC) medications are drugs that can be purchased without a prescription. While these medications are generally safe, some of them can cause elevated creatinine levels. Common OTC medications that can cause elevated creatinine levels include acetaminophen and ibuprofen.

Acetaminophen

Acetaminophen is a common OTC pain reliever and fever reducer. It is generally safe when used as directed, but it can cause elevated creatinine levels in some people. This is because the drug can interfere with the kidneys’ ability to filter out creatinine, leading to higher levels in the blood.

Ibuprofen

Ibuprofen is another common OTC pain reliever and fever reducer. It is also generally safe when used as directed, but it can also interfere with the kidneys’ ability to filter out creatinine, leading to elevated levels in the blood. People who take ibuprofen regularly should be aware of the potential risks of elevated creatinine levels.

What Prescription Drugs can Cause High Creatinine Levels?

Prescription medications are drugs that must be prescribed by a doctor. Some of these drugs can cause elevated creatinine levels, and it is important to be aware of the potential risks before taking any prescription medication. Common prescription medications that can cause elevated creatinine levels include aminoglycosides, cyclosporine, and ciprofloxacin.

Aminoglycosides

Aminoglycosides are a class of antibiotics that are commonly used to treat bacterial infections. These drugs can interfere with the kidneys’ ability to filter out creatinine, leading to elevated levels. Common aminoglycosides that can cause elevated creatinine levels include gentamicin, tobramycin, and amikacin.

Cyclosporine

Cyclosporine is a medication that is commonly used to suppress the immune system and treat autoimmune diseases. This drug can interfere with the kidneys’ ability to filter out creatinine, leading to elevated levels. People who take cyclosporine should be aware of the potential risks of elevated creatinine levels.

What Supplements can Cause High Creatinine Levels?

Supplements are substances that are taken in addition to a person’s regular diet. Some of these supplements can cause elevated creatinine levels, and it is important to be aware of the potential risks before taking any supplement. Common supplements that can cause elevated creatinine levels include creatine, B vitamins, and caffeine.

Creatine

Creatine is a dietary supplement that is commonly used to increase muscle mass and improve athletic performance. This supplement can interfere with the kidneys’ ability to filter out creatinine, leading to elevated levels. People who take creatine should be aware of the potential risks of elevated creatinine levels.

B Vitamins

B vitamins are a group of vitamins that are essential for many bodily functions. These vitamins are commonly taken as supplements, but can interfere with the kidneys’ ability to filter out creatinine, leading to elevated levels. Common B vitamins that can cause elevated creatinine levels include thiamine, riboflavin, and folate.

What Herbal Supplements can Cause High Creatinine Levels?

Herbal supplements are substances derived from plants that are taken to improve health or treat medical conditions. Some of these supplements can cause elevated creatinine levels, and it is important to be aware of the potential risks before taking any herbal supplement. Common herbal supplements that can cause elevated creatinine levels include ginseng, ginkgo biloba, and St. John’s wort.

Ginseng

Ginseng is an herbal supplement that is commonly taken to improve energy and boost the immune system. This supplement can interfere with the kidneys’ ability to filter out creatinine, leading to elevated levels. People who take ginseng should be aware of the potential risks of elevated creatinine levels.

Ginkgo Biloba

Ginkgo biloba is an herbal supplement that is commonly taken to improve memory and mental function. This supplement can interfere with the kidneys’ ability to filter out creatinine, leading to elevated levels. People who take ginkgo biloba should be aware of the potential risks of elevated creatinine levels.

Related Faq

What is Creatinine?

Creatinine is a byproduct of muscle metabolism and is usually excreted from the body in the urine. It is used as a measure to assess kidney function, as higher levels of creatinine can indicate kidney problems. When creatinine levels are abnormally elevated, it can be an indication that certain drugs may be contributing to kidney damage.

What Drugs Cause Elevated Levels of Creatinine?

There are several drugs that can cause elevated levels of creatinine. These drugs include non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen, as well as certain antibiotics, such as ciprofloxacin, amoxicillin, and gentamicin. Other drugs, such as those used to treat hypertension and heart failure, can also cause elevated creatinine levels. Additionally, some over-the-counter dietary supplements, such as creatine and whey protein, may also lead to elevated creatinine levels.

What are the Potential Side Effects of Elevated Creatinine Levels?

The potential side effects of elevated creatinine levels include increased risk of kidney damage, increased risk of dehydration, and increased risk of kidney stones. Additionally, elevated creatinine levels can lead to a buildup of toxins in the bloodstream, which can cause nausea, vomiting, and fatigue.

How is Elevated Creatinine Treated?

The treatment of elevated creatinine levels depends on the cause of the elevation. If the cause is a drug, then the drug should be ceased or the dosage adjusted. If the cause is an underlying medical condition, then that condition should be treated. Additionally, lifestyle modifications such as reducing dietary salt, increasing fluid intake, and reducing alcohol consumption may help to reduce creatinine levels.

What Are Some Preventative Measures for Elevated Creatinine Levels?

To prevent elevated creatinine levels, it is important to follow the instructions of your doctor and to be aware of potential side effects of any drugs you are taking. Additionally, it is important to maintain a healthy diet and lifestyle, as this can help to reduce creatinine levels.

What Should I Do if I Suspect Elevated Creatinine Levels?

If you suspect that you may have elevated creatinine levels, it is important to speak to your doctor to receive a proper diagnosis. This may require a creatinine blood test and other laboratory tests. Additionally, your doctor may need to review your medical history, current medications, and lifestyle factors to determine the cause of the elevated creatinine levels.

Drugs that cause elevated levels of creatinine can be dangerous to your health and should be treated with caution. If you are experiencing unusually high levels of creatinine, you should consult with your doctor to try to identify the underlying cause and make any necessary lifestyle changes to lower your creatinine levels. With the right treatment, you can ensure that your body retains its healthy balance of creatinine and prevent any potential health risks.

Mark Halsey is a licensed therapist, founder, and chief editor of Clean Break Recovery. With over a decade of addiction treatment experience, Mark deeply understands the complex needs of those struggling with addiction and utilizes a comprehensive and holistic approach to address them. He is well-versed in traditional and innovative therapies, including cognitive-behavioral therapy, motivational interviewing, and mindfulness-based interventions.

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